A truck driver is dead after a crash involving multiple vehicles on a major Victorian road yesterday.

It’s believed a B-double truck collided with a road-worker’s truck before it veered across the median strip, clipped a car, and crashed.

The B-double truck driver, who is yet to be formally identified, died at the scene, police confirmed overnight.

A truck crash has closed the Hume Freeway at Violet Town. (Nine)

Two adults and two children were transported to hospital in Wangaratta for treatment.

They were in a stable condition, according to a statement from Ambulance Victoria.

“A man in his 50s was transported by road ambulance to Goulburn Valley Health in a stable condition,” a spokesperson added.

Police said four occupants of the car were taken to hospital for observation, and the driver of the roadworks vehicle was taken to hospita with non-life-threatening injuries.

Six Country Fire Authority units were on scene along with police, SES and ambulances.

Violet Town is a country town south of Shepparton.

“Northbound traffic should detour via the Goulburn Valley Highway through Seymour to Shepparton then return via Benalla on the Midland Hwy,” a statement from VicTraffic said.

“Southbound should exit at Violet Town and use the Murchison-Violet Town Road to the Goulburn Valley Highway, and rejoin the Hume in Seymour.”

The detour would add about 45 minutes of driving time for those on the road.

No update to this alert has been posted on VicTraffic’s X page.

The Hume Freeway connects Sydney and Melbourne and is one of the busiest freight routes in the country.

Thousands of trucks use the freeway everyday.