A drone shot of a car next to a mine shaft opening.

Police have not ruled out returning to Andamooka as the investigation continues.  (Supplied: SA Police)

 vehicle has been seized as the search for missing South Australian Trisha Graf continues.

Police wound up a renewed two-day search for evidence relating to the suspicious disappearance of the 41-year-old, who has been missing since December 12 in the SA outback.

A vehicle of interest was seized at Andamooka on Thursday and will be forensically examined.

Missing woman Trisha Graf.

Members from Major Crime Investigation Branch and STAR Group have resumed searching for Trisha Graf. (Supplied: SA Police)

Over the past two days South Australia Police’s special tasks and rescue (STAR) officers, major crime investigators and SES members searched 315 points of interest including mine shafts and disused diggings.

While no evidence was recovered during the ground searches, police have not ruled out returning to the area as the investigation continues.

Several officers with metal detectors going over disturbed earth

Authorities search mine shafts and disused diggings for evidence of Trisha Graf. (Supplied: SA Police)

In February police were able to search a septic tank at an Andamooka address, which failed to turn up further evidence.

That search was subsequently forced to conclude early due to heavy rains.

A drone shot of a waste storage tank emptying a septic tank while three officers observe.

In February police searched a septic tank at a residential address in Andamooka, but no evidence was located. (Suplied: SA Police)

Ms Graf was last seen driving in Andamooka on December 12 before her car was found abandoned near Blue Dam, about 40 kilometres east of Roxby Downs, the following day.

However, her disappearance was not declared a major crime until January.

In a previous statement, police said Ms Graf had spent some time at the Roxby Downs Hotel, where she was seen about 12:20am on December 12, before leaving a short time later with a friend.

“After leaving the hotel, Trisha travelled from Roxby Downs towards Andamooka before colliding with a kangaroo a short distance from the Andamooka township,” a SAPOL spokesperson said.

A photos of a white four wheel drive car with a damaged front end stuck on top of a mound of dirt on a projector.

In January, police declared the disappearance of Trisha Graf a major crime. (ABC News: Carl Saville)

“After striking the kangaroo, Trisha and her friend continued onto Andamooka, where they visited a home in the north-western area of the town.

“After a short time, Trisha left just before 2am to travel the short distance home.”

Police said anyone with information should contact Crime Stoppers on 1800 333 000.