A woman has died following a head-on crash in NSW’s south, with several others left seriously injured.

Emergency services were called to the intersection of Hume Highway and Yass Valley Way at Manton, about 10km north of Yass, shortly before 1.45pm on Saturday.

Police said a Mazda sedan and a Ford station wagon collided head-on, confirming a 69-year-old passenger had died at the scene.

Paramedics treated the driver of the Mazda, a 37-year-old man, for chest and pelvis injuries before he was taken to Canberra Hospital in a critical condition.

A woman in her 30s, who was also in the Mazda, was treated at the scene before being airlifted to Canberra Hospital in a critical condition.

A second passenger, a 70-year-old man, was treated by paramedics and taken to hospital in a serious condition.

The driver of the Ford, a 32-year-old woman and the sole occupant, suffered minor injuries and was transported to Canberra Hospital for further treatment.

“A crime scene has been established and will be examined by officers from the Southern Crash Investigation Unit,” police confirmed in a statement.

Officers from The Hume Police District will prepare a report for the information of the Coroner.

Police are asking anyone with information or relevant dashcam footage to contact Crime Stoppers on 1800 333 000.