Police are still searching for a car and driver involved in a hit-and-run that has left a Melbourne father with serious head injuries in hospital.

In CCTV footage seen by 9News, the father and some friends were standing on the road near a car on Westphalian Rise in Clyde North about 1am today, when the occupants of a dark-coloured hatchback or SUV hurled abuse as they drove past.

The car did an abrupt U-turn before driving straight towards the men, collecting the 29-year-old father-of-four.

The car did an abrupt U-turn before driving straight towards the men, collecting the 29-year-old father-of-four.© 9News

Neighbours rushed to help him as he lay unconscious on the road, while the car and its occupants sped off.

The man was taken to Alfred Hospital, where he had emergency surgery to his head.

He remains in intensive care in a serious but stable condition.

According to the victim’s family, the man had just returned home from celebrating his father’s engagement.

The car involved and the people inside haven’t been found.

It is not clear if the two parties were known to each other.

Neighbours said they were shocked by the incident, and were appalled the man was left seriously injured on the road.

“That’s really bad behaviour,” neighbour Kamal said.

“Even [if it’s] accidentally happened, they stop and help, that’s the Australian culture.”

“I feel not safe anymore.”

A crime scene has been established, and police are urging anyone with information or footage of the incident to contact Crime Stoppers.