Neighbours have described chaotic scenes and multiple gunshots as police shot dead a 21-year-old man armed with a knife during a welfare check at his home in Brisbane’s east.

The witnesses confirmed the man had a large kitchen knife and had lunged at officers, and reported seeing police attempting CPR on him before he was declared dead.

Officers were conducting a mental health check at the home in Thurston St, Tingalpa, about 10.30am on Tuesday, Queensland Police Service said.

“Police attempted to negotiate with the man, however … the man made threats towards police while armed with a knife and he was shot,” police said.

“Medical assistance was immediately rendered, however, the man died at the scene.”

Police said one of the officers was injured in the incident but will make a “full recovery”.

A crime scene has been declared.

Witnesses reported hearing what sounded like up to 10 shots.

Police and emergency services at a property in Tingalpa during the ongoing investigation.Police and emergency services at a property in Tingalpa during the ongoing investigation. Credit: 7NEWS

“Oh my god … I am shaking … they’ve shot someone outside my house,” one neighbour is heard saying in a video provided to 7NEWS.

“I don’t know what’s going on. They are doing CPR on him now.”

Tradesperson Zane Rogers, who was working next door, said: “I went around the back and heard 10 shots.

“Then I sort of heard him … screaming in pain and then, yeah, I guess 15 minutes later he wasn’t alive.

“I knew something was going to happen … because I heard police say he’s got a knife in the house before he even came out of the house.”

Officers remain on scene at a Thurston St home following a serious police incident.Officers remain on scene at a Thurston St home following a serious police incident. Credit: 7NEWS

Queensland Police acting Chief Superintendent Heath McQueen said it was a “devastating incident” for the man’s family and emergency services, and a stark reminder of the “inherent danger” police face daily.

“These officers were confronted with an extraordinarily dangerous situation and they should be very proud of the way that they’ve responded,” Queensland Police Union president Shane Prior added.

He said a taser was used on the man before he was shot but was ineffective.

“While trying to detain that person, that male person has lunged at police with a knife,” Prior said.

The number of shots fired will be examined as part of an Ethical Standards Command investigation into the incident on behalf of the State Coroner, overseen by the Crime and Corruption Commission.

A crime scene remained in place on Wednesday morning.

The incident comes after two police shootings in NSW, with a man shot in the shoulder during an arrest in Newcastle on Tuesday morning, and another man shot dead in Sydney’s Potts Point just hours later.