A person has died and another is fighting for life after a horror two-car crash that shut down a major highway in both directions.

Emergency services were called to the Old Hume Highway at South Camden, about 65km south-west of Sydney, about 11.30 on Saturday.

The highway is closed in both directions at the intersection of Camden Bypass.

Drivers are being diverted via Burragorang Road and Cawdor Road.

‘Ongoing police investigations are expected to take some time,’. Transport for NSW said in statement on its website.

Motorists have been told to avoid the area.

In footage from the scene, a cream and a red hatchback are seen with significant damage. One of the vehicle’s windshield has been completely shattered.

A man was seen being consoled by bystanders at the scene.

Police and Fire and Rescue NSW have erected large tents at the crash site.

Daily Mail has contacted NSW Police in relation to the crash.

Both of the vehicles involved in the crash have sustained significant damage

Police and fire crews were called to the major highway south-west of Sydney about 11.30am

A man was seen being consoled by a witness at the scene following the crash

The man was seen putting his hands on his head at one point

Emergency responders are seen erecting a Fire and Rescue NSW tent at the scene

Dozens of police officers were at the scene in South Camden on Saturday

The Old Hume Highway is expected to be closed for some time