The plane crash occurred near Muhammad Ali International Airport in Louisville.

The plane crashed in Louisville (Image: X)

Footage has shown the horrifying moment a cargo plane in Louisville exploded as it crashed near Muhammad Ali International Airport in Louisville.

Louisville Metro Police Department has reported injuries as emergency services continue their response.

They said in a statement: “LMPD and multiple other agencies are responding to reports of a plane crash near Fern Valley and Grade Lane. Grade lane will be closed indefinitely between Stooges and Crittenden. Injuries reported.”

Police also told locals to “stay away” and issued a shelter-in-place warning.

Meanwhile, the Federal Aviation Administration (FAA) confirmed that the aircraft involved in the crash was UPS Flight 2976, travelling to Honolulu.

A statement read: “The FAA and National Transportation Safety Board (TSB) will investigate.

“The NTSB will lead the investigation and will provide all updates. This information is preliminary and subject to change.”

UPS said in a statement: “At approximately 5:20 PM ET tonight, UPS Flight 2976 from Louisville, KY, to Honolulu, an MD-11 with three crewmembers onboard, was involved in an accident in Louisville. At this time, we have not confirmed any injuries/casualties.

“UPS will release more facts as they become available, but the National Transportation Safety Board is in charge of the investigation and will be the primary source of information about the official investigation.”

Images on news channels showed the scene of the crash (Image: X)

Smoke billowing above the wreckage (Image: X)

Eyewitness footage of the crash (Image: X)

Local media shared footage from the site of the crash showing a long trail of flames as the fire service tries to douse the blaze.

Videos shared online also showed the moment buildings appeared to go up in flames following the impact of the crash.

At least 25,000 gallons of jet fuel were onboard the plane when it took off, according to reports.

Kentucky Governor Andy Beshear said: “Kentucky, we are aware of a reported plane crash near Louisville International Airport.

“First responders are onsite, and we will share more information as available. Please pray for the pilots, crew and everyone affected. We will share more soon.”