Two of the girls are ‘known to each other’ and went missing on the same night however all cases aren’t believed to be linked.

Police have launched pleas to help locate four girls missing from Western Sydney in the past fortnight.

Police have called on the public for help locating four young girls who have gone missing across Western Sydney in a matter of weeks.

Two of the girls, Rose and Connie, both vanished from Liddle St in St Marys on Wednesday.

Police told 7NEWS.com.au the girls are known to each other.

Connie, 11, is described as being of Aboriginal or Torres Strait Islander appearance, about 155cm tall with a think build and long dark brown hair.

Rose, 13, is also described as being of Aboriginal or Torres Strait Islander appearance, about 145cm tall with an average build and long dark brown hair.

Both girls are known to frequent St Marys and Redfern.

It comes after the disappearance of 17-year-old Jadea Gillon on May 25 from Verills Gr in Oakhurst, about 6km east of the girls’ last known location.

Rose, 13, and Connie, 11, have been missing from St Marys since Wednesday.Rose, 13, and Connie, 11, have been missing from St Marys since Wednesday. Credit: NSW Police Jadea Gillon and Shay-Lee Hosa, both aged 17, vanished from Western Sydney in the weeks prior to Rose and Connie.Jadea Gillon and Shay-Lee Hosa, both aged 17, vanished from Western Sydney in the weeks prior to Rose and Connie. Credit: NSW Police

Gillon is known to frequent the Plumpton area and is described as Caucasian, about 155cm tall, with a slim build and shoulder-length light brown hair.

She vanished just three days after another 17-year-old girl, Shay-Lee Hosa.

Hosa was last seen on George St in Parramatta and is described as Caucasion, about 165cm tall, with a slim build and shoulder-length blonde fair. She is known to frequent Blacktown and Warwick Farm.

Police hold concerns for each girl and told 7NEWS.com.au there was no indication the cases of Hosa and Gillion were linked to either Connie or Rose.

Anyone with information regarding the missing persons cases have been urged to contact Crime Stoppers.