A massive has erupted in the Newcastle sparking a massive response with more than 60 firefighters dispatched to battle the blaze.

Emergency crews were called to the corner of Denison St and Maitland Rd in the suburb Mayfield shortly after 3.30pm on Monday.

Vision from area shows the flames reaching four-storeys high erupting from a whitegoods warehouse situated between homes and apartment buildings.

Police established a 200m exclusion zone as crowds gathered while fire crews worked to contain the blaze.

The effort was still ongoing about 7.30pm though it has not spread to other buildings.

Road closures are expected to last well into Monday night.

‘Residents within 1km of the location are urged to close doors and windows to mitigate any smoke, fumes or embers entering their homes,’ NSW police said.

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‘Motorists are urged to avoid the area.’

A large fire has broken out in a residential street in Newcastle

Police has closed off parts of the suburb of Mayfield with more than 60 firefighters battling the inferno

The fire has been contained to one building and has not spread to residential buildings nearby but the operation was still underway about 7.30pm

What caused the blaze will be the subject of an investigation.

There have also been electricity outages in the area with Ausgrid working to restore services.

There are no reports of injuries connected to the fire.